Key result
Electrical stimulation with direct current or negative current injection into a single endothelial cell evoked vasodilation (16 ± 2 µm) and hyperpolarization (11 ± 1 mV) along hamster feed arteries.
Population
Feed artery segments of the hamster retractor muscle
Comparison
Electrical stimulation with direct current or… vs Stimulation at 16 Hz or endothelial cell damage
Design
Preclinical
Authors
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Endothelial electrical events may propagate vasodilation without ligands; leaves open their role in physiological or clinical vasoregulation.
Electrical events originating within a single endothelial cell can drive the relaxation of smooth muscle cells throughout the entire vessel, independent of ligand-receptor interactions.
Emerson et al. (2001) studied this question. Electrical stimulation (direct current or negative current injection) was evaluated on Vasodilation and hyperpolarization. Electrical stimulation with direct current or negative current injection into a single endothelial cell evoked vasodilation (16 ± 2 µm) and hyperpolarization (11 ± 1 mV) along hamster feed arteries.
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