Key result
KCl and phenylephrine stimulation induced identical conducted electrical responses in smooth muscle and endothelium, suggesting these cells are electrically coupled homocellularly and heterocellularly.
Population
Isolated arterioles of hamster cheek pouch in vitro
Design
Preclinical
Authors
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Supports coordinated vasomotor signaling in animal microvessels; extends coupling models but leaves open human translation.
Smooth muscle and endothelial cells in hamster cheek pouch arterioles are electrically coupled both homocellularly and heterocellularly, allowing for coordinated conducted vasomotor responses.
Xia et al. (1995) studied this question. KCl and Phenylephrine stimulation was evaluated on Resting membrane potential and conducted electrical responses. KCl and phenylephrine stimulation induced identical conducted electrical responses in smooth muscle and endothelium, suggesting these cells are electrically coupled homocellularly and heterocellularly.
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