Key result
External barium and cesium effectively blocked inward rectifier K+ currents in single smooth muscle cells from rat cerebral arteries, with barium showing a half-inhibition constant of 2.2 microM at -60 mV.
Population
Single smooth muscle cells isolated from the posterior cerebral artery of Wistar-Kyoto rats
Comparison
Elevated extracellular K+, external barium, or… vs Baseline/control conditions
Design
Preclinical
Authors
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Barium blockade profile in rat cerebrovascular myocytes extends cellular electrophysiology; leaves open relevance to human cerebral vasoregulation.
This study provides the first direct measurements of inward rectifier K+ currents in single smooth muscle cells from rat cerebral arteries and demonstrates their effective blockade by external barium ions.
Quayle et al. (1993) studied this question. External barium or cesium was evaluated on Inward rectifier K+ currents. External barium and cesium effectively blocked inward rectifier K+ currents in single smooth muscle cells from rat cerebral arteries, with barium showing a half-inhibition constant of 2.2 microM at -60 mV.
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