January 27, 2006AJP Regulatory Integrative and Comparative Physiology

Vasa recta pericytes express a strong inward rectifier K⁺ conductance

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Population

Isolated descending vasa recta (DVR) smooth muscle and pericytes

Comparison

Extracellular K+ elevation, Ba2+, Cs+, and… vs Baseline conditions

Design

Preclinical

Authors

CCChunhua CaoShanghai Jiao Tong University JGJae Hwan GooJeonnam Bioindustry Foundation WLWhaseon Lee‐KwonUlsan National Institute of Science and Technology

Discussion

Member takes

Implication

Animal data on pericyte K+ responses should not yet change practice; leaves open Kir/Na-K-ATPase roles in human renal medullary flow.

Structured PICO

Population

Isolated descending vasa recta (DVR) smooth muscle and pericytes

Intervention

Extracellular K+ elevation (from 5 to 10, 50, and 140 mmol/l), Ba2+, Cs+, and ouabain application

Comparator

Baseline conditions (e.g., 5 mmol/l extracellular K+)

Outcome

Presence and characteristics of inward rectifying K+ currents and membrane potential changessurrogate

Strong inward rectifier K+ channels and Na+-K+-ATPase contribute to the resting membrane potential and mediate K+-induced hyperpolarization in descending vasa recta pericytes.

Cite This Study

Cao et al. (2006) studied this question.

synapsesocial.com/papers/6a70f39b8031ec7bb1dcaefc https://doi.org/10.1152/ajpregu.00877.2005

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Vasa recta pericytes express a strong inward rectifier K⁺ conductance

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Vasa recta pericytes express a strong inward rectifier K⁺ conductance

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider