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June 1, 2000Cardiovascular ResearchOpen Access

An inward rectifier and a voltage-dependent K+ current in single, cultured pericytes from bovine heart

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Population

78 single, cultured bovine coronary pericytes

Design

Preclinical

Authors

NBNicolas von BeckerathInterventional / Structural Cardiology

Discussion

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Implication

Hypothesis-generating for pericyte K+ currents in coronary vasoregulation; requires in vivo and human validation before any clinical consideration.

Structured PICO

P
Population
78 single, cultured bovine coronary pericytes
I
Intervention
Patch-clamp technique in the whole-cell mode with varying extracellular K+ concentrations, barium, and 4-aminopyridine
O
Outcome
Passive electrical properties and major membrane currentssurrogate

This study provides the first patch-clamp recordings from coronary pericytes, identifying specific K+ currents that may play a role in regulating coronary blood flow.

Cite This Study

Nicolas von Beckerath (2000) studied this question.

synapsesocial.com/papers/6a75b27042ce5c1965dd97cdhttps://doi.org/10.1016/s0008-6363(00)00055-9
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