Key result
Clonidine lowered resting blood pressure (100/55 vs 122/73 mm Hg, P<0.01), muscle sympathetic nerve activity (4 vs 18 bursts/min, P<0.01), and heart rate (56 vs 62 bpm, P<0.05).
Why the study?
Does clonidine alter autonomic vasomotor tone and baroreflex regulation in normal young adults?
Population
9 normal young adults
Comparison
Clonidine vs Without clonidine (control occasion)
Design
Other
Authors
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Clonidine's autonomic effects in healthy adults warrant no practice change; leaves open baroreflex modulation in hypertension.
Does clonidine alter autonomic vasomotor tone and baroreflex regulation in normal young adults?
Absolute Event Rate: 100% vs 122%
p-value: p=<0.01
Alpha-2 adrenoceptor stimulation with clonidine greatly augments baroreflex-mediated bradycardia, likely via parasympathetic activation, and differentially affects baroreflex heart rate and vasomotor regulation.
Tank et al. (2004) studied Healthy (n=9). Clonidine vs. Without clonidine was evaluated on Resting systolic blood pressure (p=<0.01). Clonidine lowered resting blood pressure (100/55 vs 122/73 mm Hg, P<0.01), muscle sympathetic nerve activity (4 vs 18 bursts/min, P<0.01), and heart rate (56 vs 62 bpm, P<0.05).
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