Key result
T ± 𝜖 feedback control dramatically reduced fast pacing-induced cardiac alternans in computational models by utilizing induced chaotic dynamics when the control magnitude exceeded a critical threshold.
Why the study?
Does T ± 𝜖 feedback control suppress cardiac alternans in computational models?
Does T ± 𝜖 feedback control suppress cardiac alternans in computational models?
Theoretical analysis demonstrates that T ± 𝜖 feedback control can suppress pacing-induced cardiac alternans by utilizing induced chaotic dynamics.
Does not support clinical adoption of T ± 𝜖 feedback; leaves open translation of chaos-based alternans suppression beyond computational models.
The nonlinear dynamical properties of the recently proposed [Formula: see text] feedback control for suppressing cardiac alternans is investigated in detail for the discrete cardiac restitution map model and the continuous Luo–Rudy I ionic model. It is shown that cardiac alternans, induced by fast pacing, can be dramatically reduced by small changes of fixed magnitude ([Formula: see text]) under feedback control when [Formula: see text] exceeds a critical threshold. Remarkably, the suppression is achieved by utilizing the induced chaotic dynamics. Detailed information on the nature and mechanism of the control, and properties of the attractors are analyzed and discussed in the light of nonlinear dynamics.
No takes yet. Share an insight, caveat, or question.
Liang et al. (2019) studied Cardiac alternans. T ± 𝜖 feedback control was evaluated on Suppression of cardiac alternans. T ± 𝜖 feedback control dramatically reduced fast pacing-induced cardiac alternans in computational models by utilizing induced chaotic dynamics when the control magnitude exceeded a critical threshold.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: