Key result
Alternating-period feedback control significantly suppressed action potential duration alternans and intracellular calcium alternans in numerical simulations of a single cell model.
Why the study?
Does alternating-period feedback control suppress cardiac alternans in a single-cell computational model?
Does alternating-period feedback control suppress cardiac alternans in a single-cell computational model?
Alternating-period feedback control successfully suppresses action potential duration and intracellular calcium alternans in a computational single-cell model.
Premature for clinical use of feedback control; leaves open translation of single-cell alternans suppression to tissue or in vivo models.
Prolonged untreated cardiac alternans may lead to ventricular tachycardia, ventricular fibrillation or sudden cardiac death. Thus, it is important to develop an effective method for controlling alternans. In this paper, the suppression of cardiac alternans is studied using the recently proposed alternating-period feedback control scheme. Numerical simulations are performed on the Luo-Rudy dynamic (LRd) model for single cell. We showed that the action potential duration alternans and intracellular calcium alternans are significantly suppressed after the control is applied. In particular, our result suggests that the contractile force is more balanced from beat to beat after the alternans is reduced.
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Liang et al. (2016) studied Cardiac alternans. Alternating-period feedback control scheme was evaluated on Action potential duration alternans and intracellular calcium alternans. Alternating-period feedback control significantly suppressed action potential duration alternans and intracellular calcium alternans in numerical simulations of a single cell model.
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