Population
Theoretical/computational model of homogeneous cardiac tissue (one-dimensional cable geometry)
Design
Preclinical
Authors
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Limits feedback pacing control of alternans to smaller tissues; leaves open clinical translation in intact hearts.
Theoretical modeling reveals that dynamic feedback control of pacing to suppress cardiac alternans is limited by tissue size due to the formation of standing wave patterns.
Echebarria et al. (2002) studied this question.
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