March 17, 2006Physical Review LettersOpen Access

Control of Electrical Alternans in Canine Cardiac Purkinje Fibers

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Population

Isolated canine Purkinje fibers

Design

Preclinical

Authors

DCDavid J. ChristiniSUNY Downstate Health Sciences University MRMark L. RiccioThermo Fisher Scientific (United States)CCCalin A. CulianuUniversity of California, Los Angeles

Discussion

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Implication

Spatially uniform alternans control attenuates with amplitude; leaves open antiarrhythmic pacing scalability in intact hearts.

Structured PICO

Population

Isolated canine Purkinje fibers

Intervention

Pacing from one end using a feedback control method (properly timed premature stimuli)

Outcome

Extent to which alternans control can be achieved (spatial uniformity of control)surrogate

Feedback control of electrical alternans in cardiac tissue is possible but spatially limited by the wavelike nature of alternans, which has implications for antiarrhythmic pacing strategies.

Cite This Study

Christini et al. (2006) studied this question.

synapsesocial.com/papers/6a87c2e09842aaac2ffb0bc9 https://doi.org/10.1103/physrevlett.96.104101

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Control of Electrical Alternans in Canine Cardiac Purkinje Fibers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Control of Electrical Alternans in Canine Cardiac Purkinje Fibers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider