What question did this study set out to answer?

This research aims to investigate the density of I(to) in left ventricular myocytes and its relationship to inherited arrhythmias in German Shepherd dogs.

August 1, 1997Journal of Cardiovascular Electrophysiology

Decreased Density of Ito in Left Ventricular Myocytes from German Shepherd Dogs with Inherited Arrhythmias

Q: What is the clinical evidence from this study?

Population: Inherited ventricular arrhythmias. Intervention: Inherited ventricular arrhythmias vs. Unaffected relatives. Primary outcome: Density of inward rectifier (IK1), slow delayed rectifier (IKs), and transient outward current (Ito).

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Key result

Severe inherited ventricular arrhythmias in German shepherd dogs were associated with a 49% reduction in peak Ito density in epicardial myocytes and altered inactivation properties.

Authors

LFLisa C. FreemanLeeds Beckett University LPLinda M. PaciorettyBrookdale University Hospital and Medical Center NMN. Sydney MöiseHospital for Special Surgery

Discussion

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Implication

Should not change clinical practice; leaves open Ito's role in inherited arrhythmias beyond this canine model.

Key Points

This research aims to investigate the density of I(to) in left ventricular myocytes and its relationship to inherited arrhythmias in German Shepherd dogs.
Epicardial and Purkinje myocytes isolated from dogs were analyzed for I(to), IK1, and IKs densities.
Comparison was made between mildly or severely affected dogs and unaffected relatives.
Boltzmann analysis was performed to assess differences in steady-state inactivation.
Peak I(to) density at +40 mV reduced by 49% in epicardial myocytes from severely affected dogs.
Half-inactivation voltage (V1/2) shifted by +6.2 mV in epicardial cells of severely affected versus unaffected dogs.
Time constant for I(to) decay was reduced in both mildly and severely affected dogs compared to unaffected.

PICO

Population

German shepherd dogs mildly or severely affected with inherited ventricular arrhythmias, and unaffected relatives.

Exposure / Comparator

Inherited ventricular arrhythmias vs Unaffected relatives

Primary Outcome

Density of inward rectifier (IK1), slow delayed rectifier (IKs), and transient outward current (Ito)

Cite This Study

Freeman et al. (1997) studied Inherited ventricular arrhythmias. Inherited ventricular arrhythmias vs. Unaffected relatives was evaluated on Density of inward rectifier (IK1), slow delayed rectifier (IKs), and transient outward current (Ito). Severe inherited ventricular arrhythmias in German shepherd dogs were associated with a 49% reduction in peak Ito density in epicardial myocytes and altered inactivation properties.

synapsesocial.com/papers/6a23092f49ad601d9cd27400 https://doi.org/10.1111/j.1540-8167.1997.tb00848.x

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Decreased Density of Ito in Left Ventricular Myocytes from German Shepherd Dogs with Inherited Arrhythmias

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

Decreased Density of Ito in Left Ventricular Myocytes from German Shepherd Dogs with Inherited Arrhythmias

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

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