Key result
Trypanosoma cruzi infection acutely reduced the transient outward current (Ito) in canine epicardial myocytes from 10.2 to 5.5 pA/pF at 25 days post-infection.
Why the study?
Does Trypanosoma cruzi infection alter the transient outward potassium current in epicardial myocytes in a canine model?
Does Trypanosoma cruzi infection alter the transient outward potassium current in epicardial myocytes in a canine model?
Absolute Event Rate: 5.5% vs 10.2%
Acute Trypanosoma cruzi infection reversibly inhibits the transient outward potassium current in canine epicardial myocytes, providing insight into arrhythmogenesis in Chagas' disease.
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Provides mechanistic insight into Chagas arrhythmogenesis in canines; leaves open human translation and clinical relevance.
Pacioretty et al. (1995) studied Chagas' disease. Trypanosoma cruzi infection vs. Normal dogs was evaluated on Transient outward current (Ito) density at 25 days post-infection. Trypanosoma cruzi infection acutely reduced the transient outward current (Ito) in canine epicardial myocytes from 10.2 to 5.5 pA/pF at 25 days post-infection.
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