Inhibition of metabolism abolishes transient outward current in rabbit atrial myocytes

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Population

Single rabbit atrial myocytes

Comparison

Inhibitors of oxidative metabolism or absence of… vs Control conditions

Design

Preclinical

Authors

Discussion

May link metabolism to atrial currents in animals; leaves open relevance to human electrophysiology or therapies.

Population

Single rabbit atrial myocytes

Intervention

Inhibitors of oxidative metabolism (2,4-dinitrophenol 100 microM and cyanide 3 mM) or absence of ATP from the pipette

Comparator

Control conditions (presence of ATP, absence of metabolic inhibitors)

Outcome

Transient outward current (Ito) and steady-state outward currentsurrogate

Metabolic inhibition abolishes the transient outward current in rabbit atrial myocytes, suggesting ATP is required for channel activation.

Ogbaghebriel et al. (1994) studied this question.

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