January 1, 2000Canadian Journal of Physiology and Pharmacology

2,4-dinitrophenol acutely inhibits rabbit atrial Ca2+-sensitive Cl- current (ITO2)

View Full Paper

Ask AI

Bookmark

Population

Enzymatically isolated single rabbit atrial myocytes

Design

Preclinical

Authors

JRJan H. RaveslootAmsterdam University Medical Centers ERE.K. ROMBOUTSLeiden University Medical Center

Discussion

Member takes

Implication

Rapid DNP inhibition of rabbit atrial I(TO2) warrants no clinical extrapolation; hypothesis-generating for Cl- current modulation and requires human validation.

Structured PICO

Population

Enzymatically isolated single rabbit atrial myocytes

Intervention

2,4-dinitrophenol (DNP) 0.2 mM

Outcome

Inhibition of the Ca2+-sensitive Cl- current component of the transient outward current (I(TO2))surrogate

DNP acutely inhibits the Ca2+-sensitive Cl- current (I(TO2)) in rabbit atrial myocytes via a mechanism likely independent of metabolic inhibition.

Cite This Study

Ravesloot et al. (2000) studied this question.

synapsesocial.com/papers/6a87c61c533d786da9061f48 https://doi.org/10.1139/cjpp-78-10-766

View Full Paper

Ask AI

Bookmark

Implication

Rapid DNP inhibition of rabbit atrial I(TO2) warrants no clinical extrapolation; hypothesis-generating for Cl- current modulation and requires human validation.

2,4-dinitrophenol acutely inhibits rabbit atrial Ca2+-sensitive Cl- current (ITO2)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

2,4-dinitrophenol acutely inhibits rabbit atrial Ca2+-sensitive Cl- current (ITO2)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider