January 31, 1959American Journal of Physiology-Legacy Content

Metabolism and electrical activity of the heart: action of 2–4-dinitrophenol and ATP

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Population

Single cells of the sinus node, right auricle and A-V node

Comparison

2-4-dinitrophenol added to perfusion fluid, and… vs Sodium azide (used for comparison)

Design

Preclinical

Follow-up

45 minutes

Authors

WMWalmor C. De MelloNational Institutes of Health

Discussion

Member takes

Implication

DNP effects on isolated pacemaker cells should not guide therapy; leaves open whether oxidative phosphorylation maintains automaticity in vivo.

Structured PICO

Population

Single cells of the sinus node, right auricle and A-V node

Intervention

2-4-dinitrophenol (DNP) added to perfusion fluid, and a system with DNP and ATP

Comparator

Sodium azide (used for comparison)

Outcome

Electrical activity measured with microelectrodes (action potential duration, resting potential, slope of diastolic depolarization)surrogate

DNP inhibits electrical activity in cardiac pacemaker cells, an effect that is partially reversed by ATP, highlighting the role of oxidative phosphorylation in maintaining resting potential.

Cite This Study

Walmor C. De Mello (1959) studied this question.

synapsesocial.com/papers/6a9575f666ca20f6f97d0cb2 https://doi.org/10.1152/ajplegacy.1959.196.2.377

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Implication

DNP effects on isolated pacemaker cells should not guide therapy; leaves open whether oxidative phosphorylation maintains automaticity in vivo.

Metabolism and electrical activity of the heart: action of 2–4-dinitrophenol and ATP

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Metabolism and electrical activity of the heart: action of 2–4-dinitrophenol and ATP

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider