Population
Isolated perfused hog heart (Purkinje and ventricular muscle fibers)
Comparison
2,4 dinitrophenol in concentrations of 2 to 5 x… vs Baseline / washing with Tyrode's solution
Design
Preclinical
Authors
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DNP's fiber-specific effects in animal preparations caution against metabolic uncouplers in electrophysiology experiments; leaves open human translational relevance.
DNP alters transmembrane action potentials differently in Purkinje versus ventricular muscle fibers, likely due to differing metabolic energy requirements and ion channel sensitivities.
Kleinfeld et al. (1963) studied this question.
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