Key result
Metabolic inhibition and oxidant stress shifted the activation and inactivation curves of the transient outward current in rat atrial myocytes in a negative direction.
Metabolic inhibition and oxidant stress modify the activation and inactivation of the transient outward current in rat atrial myocytes, possibly mediated by a rise in intracellular calcium.
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Hypothesis-generating for atrial ion channel modulation under stress; leaves open translation to human arrhythmias.
Pike et al. (1993) studied this question. Metabolic inhibition and oxidant stress vs. Baseline/control conditions was evaluated on Inactivation and activation curves of the transient outward current (ITO). Metabolic inhibition and oxidant stress shifted the activation and inactivation curves of the transient outward current in rat atrial myocytes in a negative direction.
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