April 1, 1996Journal of Cardiovascular Pharmacology and Therapeutics

Evidence of Na Current Contribution to the Transient Outward Current in Cardiac Ventricular Myocytes

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Population

Rat ventricular myocytes

Comparison

Superfusion with tetrodotoxin, sea anemone toxin… vs Baseline whole-cell Ito recordings before drug…

Design

Preclinical

Authors

MBMohamed BoutjdirElectrophysiology ZZZhihao ZhangQufu Normal University BHBoyu HuangZhejiang University of Technology

Discussion

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Implication

In sodium-free external solutions, outward Na current contributes to the transient outward current (Ito) in rat ventricular myocytes, highlighting a methodological caveat for electrophysiological studies.

Structured PICO

Population

Rat ventricular myocytes

Intervention

Superfusion with tetrodotoxin (50 μM), sea anemone toxin ATXII (100 nM), 4-aminopyridine (5 mM), and atropine (1 μM) in sodium-free choline chloride and cobalt solutions

Comparator

Baseline whole-cell Ito recordings before drug application

Outcome

Transient outward current (Ito) amplitude and conductancesurrogate

Cite This Study

Boutjdir et al. (1996) studied this question.

synapsesocial.com/papers/6a193cd3fa25ab5db6d944f1 https://doi.org/10.1177/107424849600100209

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Evidence of Na Current Contribution to the Transient Outward Current in Cardiac Ventricular Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence of Na Current Contribution to the Transient Outward Current in Cardiac Ventricular Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider