January 1, 1997AJP Heart and Circulatory Physiology
Sodium effects on 4-aminopyridine-sensitive transient outward current in canine ventricular cells
Key result
Reduction of external sodium has no direct effect on the kinetics or gating of the 4-aminopyridine-sensitive transient outward current (Ito1) in canine midmyocardial cells.
Population
Canine midmyocardial cells
Comparison
Reduction of external sodium vs Normal external Na+
Design
Preclinical
Authors
Discussion
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Member takes
Implication
No direct Na+ effect on Ito1 in canine myocytes; leaves open indirect mechanisms or species differences for targeted follow-up.
Structured PICO
P
Population
Canine midmyocardial cells
I
Intervention
Reduction of external sodium (substitution of external Na+ or application of tetrodotoxin)
C
Comparator
Normal external Na+
O
Outcome
Kinetics, gating, and selectivity of the 4-aminopyridine-sensitive transient outward current (Ito1)surrogate
Reduction of external sodium does not directly affect the kinetics or gating of the transient outward current (Ito1) in canine midmyocardial cells, suggesting previous observations were due to loss of voltage control or intracellular Na+ facilitation.
Cite This Study
Zygmunt et al. (1997) studied this question. Reduction of external sodium or application of TTX vs. Normal external sodium was evaluated on Kinetics, gating, and selectivity of Ito1. Reduction of external sodium has no direct effect on the kinetics or gating of the 4-aminopyridine-sensitive transient outward current (Ito1) in canine midmyocardial cells.