The reduction of inward-rectifying K+ current conductance upon extracellular Na+ removal in cat ventricular myocytes is mediated by intracellular acidosis, highlighting a mechanism by which ischemia or acidosis may alter cardiac electrophysiology.
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May link Na+ to IK1 via pH in ischemia; leaves open relevance to human arrhythmogenesis.
Harvey et al. (1989) studied this question.
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