Key result
Cultured human pulmonary artery smooth muscle cells demonstrate voltage-dependent K+-selective outward and Na+-selective inward currents.
Why the study?
Voltage-dependent transient outward and inward currents in human pulmonary artery smooth muscle cells were characterized to understand their electrophysiological properties.
Cultured human pulmonary artery smooth muscle cells possess voltage-dependent currents characteristic of K+-selective fast transient outward and Na+-selective inward currents.
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Does not change clinical practice; leaves open the functional role of these currents in pulmonary vascular disease.
James et al. (1995) studied Cultured cells from human pulmonary artery smooth muscle. 4-aminopyridine (4-AP) was evaluated on Voltage-dependent transient outward current (I(to)) and inward current (I(in)). Cultured human pulmonary artery smooth muscle cells possess voltage-dependent currents characteristic of K+-selective fast transient outward and Na+-selective inward currents.
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