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May 1, 1989The Journal of PhysiologyOpen Access

A voltage‐dependent outward current with fast kinetics in single smooth muscle cells isolated from rabbit portal vein.

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Population

Single smooth muscle cells isolated enzymatically from the rabbit portal vein

Design

Preclinical

Authors

DBDavid J. BeechVascular / Pulmonary VascularTBT. B. BoltonElectrophysiology

Discussion

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Implication

Extends A-current to vascular smooth muscle; leaves open its role in vasomotor regulation.

Structured PICO

P
Population
Single smooth muscle cells isolated enzymatically from the rabbit portal vein
I
Intervention
Voltage-clamp depolarization using the whole-cell configuration of the patch-clamp technique
O
Outcome
Characterization of the fast transient outward current (Ifo) kinetics, voltage dependence, and pharmacologysurrogate

Identifies and characterizes a fast transient outward potassium current (A-current) in rabbit portal vein smooth muscle cells, previously described only in neurons.

Cite This Study

Beech et al. (1989) studied this question.

synapsesocial.com/papers/6a70dd12e5469ee92be189fahttps://doi.org/10.1113/jphysiol.1989.sp017623
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cellular calcium regulates outward currents in rabbit intestinal smooth muscle cell1987 · 105 citations
  2. 2M‐currents and other potassium currents in bullfrog sympathetic neurones1982 · 516 citations
  3. 3Ionic Currents in Molluscan Soma1980 · 328 citations
  4. 4A fast transient outward current in the rat sympathetic neurone studied under voltage‐clamp conditions.1985 · 223 citations
  5. 5Some properties of the smooth muscle of rabbit portal vein1968 · 132 citations