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August 1, 1992The Journal of PhysiologyOpen Access

A potential‐dependent fast outward current in single smooth muscle cells isolated from the newborn rat ileum.

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Population

Single smooth muscle cells isolated from newborn and adult rat ileum

Comparison

Electrophysiological characterization using… vs Baseline conditions in normal physiological salt…

Design

Preclinical

Authors

SSSmirnov SvRutgers, The State University of New JerseyAZAlexander V. ZholosTaras Shevchenko National University of KyivMSM. F. ShubaNational Academy of Sciences of Ukraine

Discussion

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Implication

Characterizes distinct K+ currents in neonatal rat ileum; leaves open their role in human gut motility.

Structured PICO

P
Population
Single smooth muscle cells isolated from newborn and adult rat ileum
I
Intervention
Electrophysiological characterization using voltage clamp, ion substitution (Ca2+, Mg2+ removal), and K+ channel blockers (TEA+, 4-aminopyridine)
C
Comparator
Baseline conditions in normal physiological salt solutions
O
Outcome
Characteristics of whole-cell outward currents (delayed I(do) and fast inactivating I(fo))surrogate

This study characterizes the electrophysiological properties of two distinct outward potassium currents in newborn rat ileal smooth muscle cells.

Cite This Study

Sv et al. (1992) studied this question.

synapsesocial.com/papers/6a89cc5d5c4c6b099dec81eehttps://doi.org/10.1113/jphysiol.1992.sp019280
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Membrane currents recorded from a fragment of rabbit intestinal smooth muscle cell1986 · 86 citations
  2. 2Calcium‐activated potassium channels in single smooth muscle cells of rabbit jejunum and guinea‐pig mesenteric artery.1986 · 303 citations
  3. 3Characteristics of transient outward currents in single smooth muscle cells from the ureter of the guinea‐pig.1990 · 71 citations
  4. 4A voltage‐dependent outward current with fast kinetics in single smooth muscle cells isolated from rabbit portal vein.1989 · 87 citations
  5. 5Two components of potassium current activated by depolarization of single smooth muscle cells from the rabbit portal vein.1989 · 169 citations