Key result
Estrogen replacement therapy in postmenopausal women was associated with significantly lower mean coronary calcium content (P=0.002) and plaque area (P<0.0001) compared to untreated women.
Why the study?
Does estrogen status reduce coronary calcium content and atherosclerotic plaque area in women?
Population
56 deceased white women age 18-98 years. Exclusions: coronary stents, coronary artery bypass surgery, and…
Comparison
Estrogen replacement therapy or premenopausal… vs Untreated postmenopausal women
Design
Cross-sectional
Authors
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Estrogen replacement was associated with less coronary calcium and plaque; hypothesis-generating and requires randomized trials before any practice change.
Observational (n=56)
Does estrogen status reduce coronary calcium content and atherosclerotic plaque area in women?
p-value: p=0.002
Estrogen status is independently associated with lower coronary calcium content and plaque area in women, suggesting it may slow the progression of atherosclerosis.
Christian et al. (2002) conducted an observational in Coronary atherosclerosis (n=56). Estrogen replacement therapy vs. Untreated postmenopausal women was evaluated on Coronary calcium content and atherosclerotic plaque area (p=0.002). Estrogen replacement therapy in postmenopausal women was associated with significantly lower mean coronary calcium content (P=0.002) and plaque area (P<0.0001) compared to untreated women.
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