Key result
CABG shows no benefit over PCI for in-hospital composite outcomes despite fewer unscheduled revascularizations.
Why the study?
To analyze the results of various revascularization techniques performed during the first 24 hours in patients with high-risk non-ST-segment elevation acute coronary syndromes.
Does CABG reduce repeated revascularizations and mortality compared to PCI in high-risk NSTE-ACS patients treated within 24 hours of hospitalization?
Cohort (n=90)
No
Does CABG reduce repeated revascularizations and mortality compared to PCI in high-risk NSTE-ACS patients treated within 24 hours of hospitalization?
Answers are grounded in this paper and cite their sources.
In high-risk NSTE-ACS patients treated within 24 hours, CABG provides greater freedom from repeated revascularization compared to PCI, despite more severe baseline coronary lesions, with no significant difference in short-term mortality.
Aim. To analyze the results of various revascularization techniques in high-risk non – STsegment elevation in acute coronary syndromes performed during the first 24 hours. Methods. As a part of a single-center retrospective study, 45 cases of coronary artery bypass grafting (CABG) were examined in high-risk non – ST-segment elevation in acute coronary syndromes patients during the first 24 hours since their hospitalization for the period from 2017 to 2020. 45 cases of percutaneous coronary intervention (PCI) were selected from a similar group of patients with the help of the copy-pair method. Results. The groups were comparable according to such significant factors as age, gender, postinfarction cardiosclerosis, diabetes mellitus, and multifocal atherosclerosis. However, the severity of coronary atherosclerosis according to the Syntax score was significantly higher in the CABG group (p = 0.0004). The groups were comparable in achieving complete revascularization (p = 0.2). In 8.9% (n = 4) of patients in the PCI group, unscheduled repeated revascularization was required, and in 15.6% (n = 7) of cases stent restenosis/thrombosis was detected during the hospital period and between PCI stages, while in the CABG group, congenital malformations and dysfunction were not found. Mortality in the groups did not differ significantly (4 (8.8%) versus 2 (4.4%), p = 0.4). Conclusion. CABG provides freedom from repeated revascularizations, despite the initially more severe coronary lesion.
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Nishonov et al. (2021) conducted a cohort in High-risk non-ST-segment elevation acute coronary syndrome (NSTE-ACS) (n=90). Coronary artery bypass grafting (CABG) vs. Percutaneous coronary intervention (PCI) was evaluated on Combined endpoint (death, myocardial infarction, stroke, repeated revascularization) (p=0.75). Coronary artery bypass grafting prevented unscheduled revascularizations compared to PCI, with no significant difference in the combined hospital endpoint (13.3% vs 11.1%, p=0.75).
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