Key result
Sleep-related breathing disorder severity was associated with a blunted heart rate response to exercise, reduced by -0.09 beats/min for every SRBD unit at maximal load (p<0.001).
Why the study?
Does sleep-related breathing disorder severity affect cardiovascular reactivity during graded exercise in patients at a Sleep Disorders Center?
Cross-Sectional (n=1,149)
No
Does sleep-related breathing disorder severity affect cardiovascular reactivity during graded exercise in patients at a Sleep Disorders Center?
Effect estimate: -0.07 and -0.09 beats/min for every SRBD unit at 110 W and maximal load, respectively
p-value: p=<0.001
Sleep-related breathing disorder is independently associated with a blunted heart rate response and increased blood pressure reactivity during exercise.
SRBD severity may blunt exercise HR response in referred patients; leaves open causality and whether treatment modifies reactivity.
BACKGROUND: This study addressed the hypothesis that cardiovascular reactivity during graded bicycle exercise is influenced by a coexisting sleep-related breathing disorder (SRBD). METHODS: Blood pressure and heart rate were assessed at rest and during graded exercise (110 W and maximal load) in 1,149 patients of a Sleep Disorders Center. The degree of SRBD, and potential confounders, including blood gases and pulmonary function, were determined. RESULTS: Maximal exercise capacity tended to decrease with SRBD activity (p = 0.07). The heart rate reactivity was blunted and reduced by -0.07 and -0.09 beats/min for every SRBD unit at 110 W (p < 0.001) and at maximal load (p < 0.001), respectively. Systolic and diastolic blood pressure reactivity at maximal load were positively associated with SRBD severity. These associations were independent of possible confounders. CONCLUSION: SRBD is associated with reduced physical working capacity and a modified hemodynamic response to exercise.
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Grote et al. (2004) conducted a cross-sectional in Sleep-Related Breathing Disorder (n=1,149). Sleep-related breathing disorder (SRBD) vs. Lower SRBD severity or absence of SRBD was evaluated on Heart rate reactivity during graded bicycle exercise (-0.07 and -0.09 beats/min for every SRBD unit at 110 W and maximal load, respectively, p=<0.001). Sleep-related breathing disorder severity was associated with a blunted heart rate response to exercise, reduced by -0.09 beats/min for every SRBD unit at maximal load (p<0.001).
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