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Comprehensive mapping of immune cell dynamics reveals age-imprinted resilience in Egyptian rousette bats, suggesting new insights into cellular immunity.
T cells dominate as bats reach adulthood. Despite differing frequencies, phagocytosis of circulating and tissue-resident myeloid cells and proliferation of peripheral and splenic lymphocytes are analogous in juvenile and adult ERBs. We provide a comprehensive map of the immune landscape in ERBs and show age-imprinted resilience progression and find that variability in cellular immunity only partly recapitulates mammalian archetypes.
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Friedrichs et al. (2022) studied this question.
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