Key result
Adult age was associated with a higher frequency of dual AV nodal physiology compared to young mice <8 weeks (58% vs 27%, P=0.03).
Population
30 immature and 19 mature mice (total n=49)
Comparison
Transvenous in vivo electrophysiologic study vs Immature vs mature mice
Design
Preclinical
Authors
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May underlie lower pediatric AVNRT incidence; leaves open human translation from this animal model.
Observational (n=49)
Absolute Event Rate: 58% vs 27%
p-value: p=0.03
Mice exhibit age-related maturation of AV nodal physiology similar to humans, with increased frequency of dual AV nodal physiology in adults, which may help explain the relative rarity of AVNRT in younger pediatric populations.
Maguire et al. (2000) conducted an observational in AV nodal physiology (n=49). Adult age vs. Young age (<8 weeks) was evaluated on Frequency of dual AV nodal physiology (discontinuous A2V2 conduction curves or AV nodal echo beats) (p=0.03). Adult age was associated with a higher frequency of dual AV nodal physiology compared to young mice <8 weeks (58% vs 27%, P=0.03).
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