Key result
Thioridazine overdose was associated with significantly higher odds of prolonged QTc > 450 ms (OR 4.7; 95% CI 2.7-7.9; P=0.001) and arrhythmias compared to other neuroleptics.
Why the study?
Does thioridazine overdose increase cardiotoxicity (ECG changes and arrhythmias) compared to other neuroleptics in adult patients with neuroleptic poisoning?
Population
299 consecutive adult patients with neuroleptic poisoning presenting to metropolitan hospitals in Newcastle…
Comparison
Thioridazine overdose vs Overdose of other neuroleptics
Design
Cohort
Authors
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Thioridazine overdose may warrant ECG monitoring; leaves open confirmation in prospective studies.
Cohort (n=299)
Yes
Does thioridazine overdose increase cardiotoxicity (ECG changes and arrhythmias) compared to other neuroleptics in adult patients with neuroleptic poisoning?
Odds Ratio: 4.7 (95% CI 2.7–7.9)
p-value: p=0.001
In overdose, thioridazine is associated with significantly greater cardiotoxicity, including QT prolongation, QRS widening, and arrhythmias, compared to other neuroleptics.
Buckley et al. (1995) conducted a cohort in Neuroleptic poisoning (n=299). Thioridazine vs. Other neuroleptics was evaluated on Prolonged QTc > 450 ms1/2 (OR 4.7, 95% CI 2.7-7.9, p=0.001). Thioridazine overdose was associated with significantly higher odds of prolonged QTc > 450 ms (OR 4.7; 95% CI 2.7-7.9; P=0.001) and arrhythmias compared to other neuroleptics.
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