Key result
Body surface mapping in two patients with idiopathic long QT syndrome revealed that T wave alternans were related to alternate heterogeneous prolongation of action potential duration in the left frontal chest.
Why the study?
What are the spatial characteristics of T wave alternans in patients with idiopathic long QT syndrome as assessed by body surface mapping?
Case Report (n=2)
What are the spatial characteristics of T wave alternans in patients with idiopathic long QT syndrome as assessed by body surface mapping?
Body surface mapping demonstrates that T wave alternans in idiopathic long QT syndrome is related to alternate heterogeneous prolongation of the action potential duration in the left frontal chest.
Answers are grounded in this paper and cite their sources.
Supports hypothesis of regional APD heterogeneity in idiopathic LQTS; leaves open whether body surface mapping aids risk stratification.
Body surface mapping was recorded during T wave alternans in two patients with idiopathic long QT syndrome. Eighty-seven lead ECGs of two consecutive beats during T wave alternans demonstrated that alternating changes in the morphology and polarity of the T wave existed mainly in the left frontal chest. The QRST isointegral maps of the same two consecutive beats showed alternation of a large negative area appearing mainly in the left frontal chest. These results indicate that T wave alternans in the two patients were related to alternate heterogeneous prolongation of the action potential duration in this region.
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Shimizu et al. (1996) conducted a case report in Idiopathic long QT syndrome (n=2). Body surface mapping was evaluated on T wave alternans morphology and polarity changes. Body surface mapping in two patients with idiopathic long QT syndrome revealed that T wave alternans were related to alternate heterogeneous prolongation of action potential duration in the left frontal chest.
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