Key result
Intraportal glucose delivery significantly increased net hepatic glucose uptake by two- to threefold compared to peripheral glucose delivery alone across a physiological range of insulin levels.
Why the study?
Does intraportal glucose delivery alter the relationship between net hepatic glucose uptake and insulin concentration in fasted dogs?
Does intraportal glucose delivery alter the relationship between net hepatic glucose uptake and insulin concentration in fasted dogs?
Absolute Event Rate: 5.52% vs 3.04%
p-value: p=<0.05
Intraportal glucose delivery significantly enhances net hepatic glucose uptake compared to peripheral delivery alone across a physiological range of insulin levels, indicating the 'portal signal' is a critical determinant of hepatic glucose disposal.
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Extends evidence for portal signal in canine hepatic glucose disposal; leaves open human translation and therapeutic targeting.
Myers et al. (1991) studied Healthy (fasted) (n=7). Intraportal glucose delivery vs. Peripheral glucose delivery alone was evaluated on Net hepatic glucose uptake (NHGU) at highest insulin level (p=<0.05). Intraportal glucose delivery significantly increased net hepatic glucose uptake by two- to threefold compared to peripheral glucose delivery alone across a physiological range of insulin levels.
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