Key result
Intraportal glucose delivery significantly increased net hepatic glucose uptake by two- to threefold compared to peripheral glucose delivery alone across a physiological range of insulin levels.
Why the study?
Does intraportal glucose delivery alter the relationship between net hepatic glucose uptake and insulin concentration in fasted dogs?
Population
7 conscious mongrel dogs (16-28 kg) of either sex, fasted for 42 hours.
Comparison
Combination of peripheral and intraportal… vs Peripheral glucose delivery alone with…
Design
Preclinical, Experiments carried out in a randomized fashion, 1 wk apart
Follow-up
Acute experiment (390 minutes per protocol)
Authors
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Extends evidence for portal signal in canine hepatic glucose disposal; leaves open human translation and therapeutic targeting.
Does intraportal glucose delivery alter the relationship between net hepatic glucose uptake and insulin concentration in fasted dogs?
Absolute Event Rate: 5.52% vs 3.04%
p-value: p=<0.05
Intraportal glucose delivery significantly enhances net hepatic glucose uptake compared to peripheral delivery alone across a physiological range of insulin levels, indicating the 'portal signal' is a critical determinant of hepatic glucose disposal.
Myers et al. (1991) studied Healthy (fasted) (n=7). Intraportal glucose delivery vs. Peripheral glucose delivery alone was evaluated on Net hepatic glucose uptake (NHGU) at highest insulin level (p=<0.05). Intraportal glucose delivery significantly increased net hepatic glucose uptake by two- to threefold compared to peripheral glucose delivery alone across a physiological range of insulin levels.
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