June 1, 2004AJP Regulatory Integrative and Comparative Physiology

Vagal cooling and concomitant portal norepinephrine infusion do not reduce net hepatic glucose uptake in conscious dogs

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Population

9 conscious dogs with hollow perfusable coils around their vagus nerves (group 1 n=3, group 2 n=6)

Comparison

Vagal cooling to eliminate vagal signaling, with… vs Periods of intact vagal signaling before and…

Design

Preclinical

Follow-up

150 to 180 minutes

Authors

SCSylvain CardinUnited States Army Institute of Surgical Research MPMichael J. PagliassottiColorado State University MMMary Courtney MooreVanderbilt University

Discussion

Member takes

Overview

Does not support vagal or sympathetic mediation of portal glucose effects in dogs; leaves open alternative mechanisms for further study.

Structured PICO

Population

9 conscious dogs with hollow perfusable coils around their vagus nerves (group 1 n=3, group 2 n=6)

Intervention

Vagal cooling (-15 degrees C solution) to eliminate vagal signaling, with (group 2) or without (group 1) intraportal infusion of norepinephrine at 16 ng.kg(-1).min(-1)

Comparator

Periods of intact vagal signaling (coils perfused with 37 degrees C solution) before and after cooling

Outcome

Net hepatic glucose uptake (NHGU)surrogate

Vagal efferent signaling and augmented sympathetic tone do not appear to mediate the stimulation of net hepatic glucose uptake by portal glucose delivery in conscious dogs.

Cite This Study

Cardin et al. (2004) studied this question.

synapsesocial.com/papers/6a9116129eff36e44092d2f5 https://doi.org/10.1152/ajpregu.00041.2004

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June 1, 2004AJP Regulatory Integrative and Comparative Physiology

Vagal cooling and concomitant portal norepinephrine infusion do not reduce net hepatic glucose uptake in conscious dogs

View Full Paper

Ask AI

Bookmark

Population

9 conscious dogs with hollow perfusable coils around their vagus nerves (group 1 n=3, group 2 n=6)

Comparison

Vagal cooling to eliminate vagal signaling, with… vs Periods of intact vagal signaling before and…

Design

Preclinical

Follow-up

150 to 180 minutes

Authors

SCSylvain CardinUnited States Army Institute of Surgical Research MPMichael J. PagliassottiColorado State University MMMary Courtney MooreVanderbilt University

Discussion

Member takes

Overview

Does not support vagal or sympathetic mediation of portal glucose effects in dogs; leaves open alternative mechanisms for further study.

Structured PICO

Population

9 conscious dogs with hollow perfusable coils around their vagus nerves (group 1 n=3, group 2 n=6)

Intervention

Vagal cooling (-15 degrees C solution) to eliminate vagal signaling, with (group 2) or without (group 1) intraportal infusion of norepinephrine at 16 ng.kg(-1).min(-1)

Comparator

Periods of intact vagal signaling (coils perfused with 37 degrees C solution) before and after cooling

Outcome

Net hepatic glucose uptake (NHGU)surrogate

Vagal efferent signaling and augmented sympathetic tone do not appear to mediate the stimulation of net hepatic glucose uptake by portal glucose delivery in conscious dogs.

Cite This Study

Cardin et al. (2004) studied this question.

synapsesocial.com/papers/6a9116129eff36e44092d2f5 https://doi.org/10.1152/ajpregu.00041.2004

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

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