Key result
Acute anterior sub-diaphragmatic vagus nerve stimulation increased peripheral glucose clearance rate (p<0.001) and lowered glucose levels (p<0.05) in anesthetized adult male rats.
Why the study?
Because the sub-diaphragmatic vagus innervates organs involved in glucose homeostasis, the authors investigated the effect of acute anterior trunk electrical stimulation on glucose fluxes.
Does acute sub-diaphragmatic anterior vagus nerve stimulation increase peripheral glucose uptake in anaesthetized rats?
Comparison
Vagus nerve stimulation (VNS+, n=11) vs sham stimulation (VNS-, n=11)
Design
Animal experimental study
Follow-up
120 minutes
Authors
Loading...
May support vagal neuromodulation for glucose control; hypothesis-generating in animals and leaves open human translation.
Does acute sub-diaphragmatic anterior vagus nerve stimulation increase peripheral glucose uptake in anaesthetized rats?
p-value: p=<0.001
Acute anterior sub-diaphragmatic vagus nerve stimulation increases peripheral glucose uptake in rats, independent of insulin levels.
Hoornenborg et al. (2023) studied this question. Acute electrical stimulation of the anterior trunk of the sub-diaphragmatic vagus vs. Sham stimulation was evaluated on Glucose clearance rate (GCR) (p=<0.001). Acute anterior sub-diaphragmatic vagus nerve stimulation increased peripheral glucose clearance rate (p<0.001) and lowered glucose levels (p<0.05) in anesthetized adult male rats.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: