Key result
Chronic bilateral abdominal vagus nerve stimulation reversed the 34% reduction in whole-body insulin sensitivity and 33% reduction in hepatic glucose uptake seen in obese mini-pigs (P<0.01).
Why the study?
Does chronic bilateral abdominal vagal stimulation improve insulin sensitivity in obese mini-pigs?
Population
15 adult mini-pigs (lean and diet-induced obese models)
Comparison
Permanent, bilateral, vagal stimulation at the… vs Lean nonstimulated and obese nonstimulated…
Design
Preclinical
Follow-up
12 weeks
Authors
Loading...
Chronic vagal stimulation may alter insulin sensitivity in mini-pigs; leaves open any human diabetes application.
Does chronic bilateral abdominal vagal stimulation improve insulin sensitivity in obese mini-pigs?
p-value: p=<0.01
Chronic bilateral abdominal vagal stimulation reverses obesity-associated alterations in glucose metabolism and improves insulin sensitivity in a mini-pig model.
Malbert et al. (2017) studied Obesity-associated alterations in glucose metabolism (n=15). Chronic bilateral stimulation of the abdominal vagus nerve vs. Lean nonstimulated and obese nonstimulated mini-pigs was evaluated on Whole-body insulin sensitivity and hepatic glucose uptake rate (p=<0.01). Chronic bilateral abdominal vagus nerve stimulation reversed the 34% reduction in whole-body insulin sensitivity and 33% reduction in hepatic glucose uptake seen in obese mini-pigs (P<0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: