Key result
Subdiaphragmatic vagal stimulation in fasting baboons increased inferior vena cava insulin by 50% and splenic vein insulin by 30% over resting levels, without altering blood glucose levels.
Why the study?
Does vagal stimulation increase plasma insulin and glucose levels in fasting baboons?
Population
15 fasting baboons, anaesthetized with pentobarbitone sodium
Comparison
Subdiaphragmatic stimulation of the cut right… vs Resting levels (baseline)
Design
Preclinical
Follow-up
10 min
Authors
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May enhance insulin secretion independently of glucose in primates; leaves open translation to human cardiometabolic therapies.
Does vagal stimulation increase plasma insulin and glucose levels in fasting baboons?
Vagal stimulation directly increases insulin secretion independent of hyperglycemia in a baboon model.
Daniel et al. (1967) studied this question. Subdiaphragmatic stimulation of the cut right vagal trunk vs. Resting levels was evaluated on Plasma insulin and glucose levels. Subdiaphragmatic vagal stimulation in fasting baboons increased inferior vena cava insulin by 50% and splenic vein insulin by 30% over resting levels, without altering blood glucose levels.
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