Key result
Electrical stimulation of the right and left cervical vagus and dorsal vagal trunk induced an immediate significant elevation in immunoreactive insulin concentrations in anesthetized dogs.
Why the study?
Does electrical stimulation of the vagus nerve increase insulin secretion in anesthetized dogs?
Population
Anesthetized dogs
Comparison
Electrical stimulation of the peripheral cut end… vs Unstimulated state / comparison between…
Design
Preclinical
Follow-up
Immediate
Authors
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Hypothesis-generating for vagal control of insulin; leaves open translation to human metabolic disease.
Does electrical stimulation of the vagus nerve increase insulin secretion in anesthetized dogs?
Electrical stimulation of specific vagal trunks (cervical and dorsal) directly increases insulin secretion in dogs without subsequent decreases in blood sugar levels.
KANETO et al. (1967) studied this question. Electrical stimulation of the peripheral cut end of the vagus nerve vs. Ventral vagal trunk stimulation was evaluated on Plasma insulin concentrations. Electrical stimulation of the right and left cervical vagus and dorsal vagal trunk induced an immediate significant elevation in immunoreactive insulin concentrations in anesthetized dogs.
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