Key result
Vagal nerve stimulation in a dysfunctioned canine pancreas increased insulin and glucagon secretion, whereas splanchnic and pancreatic nerve stimulation produced different or minor hormonal changes.
Population
Adult beagle canine with induced partial dysfunction of the pancreas (Type I diabetes model)
Comparison
Electrical stimulation of vagus, splanchnic, and… vs Baseline and intact pancreas state
Design
Preclinical
Follow-up
5 min after stimulation stopped
Authors
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Supports targeted neuromodulation research in diabetes models; leaves open translation to human therapy.
Electrical stimulation of specific pancreatic nerves can differentially modulate insulin and glucagon secretion in a canine model of Type I diabetes.
Rozman et al. (2002) studied Insulin-dependent Type I diabetes (induced partial dysfunction of the pancreas) (n=1). Nerve stimulation (vagus, splanchnic, and pancreatic nerves) vs. Baseline (before experiment) was evaluated on Secretion of insulin, glucagon, and C-peptide. Vagal nerve stimulation in a dysfunctioned canine pancreas increased insulin and glucagon secretion, whereas splanchnic and pancreatic nerve stimulation produced different or minor hormonal changes.
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