Why the study?
Does vagal nerve stimulation increase glucagon and insulin secretion in dogs, and what are the underlying receptor mechanisms?
Population
Halothane-anesthetized dogs
Comparison
Electrical stimulation of both ventral and… vs Baseline and comparison between pretreatment…
Design
Preclinical
Follow-up
10 minutes
Authors
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Does not support clinical vagal stimulation for glycemic control; leaves open nicotinic-muscarinic islet pathways for human metabolic research.
Does vagal nerve stimulation increase glucagon and insulin secretion in dogs, and what are the underlying receptor mechanisms?
Vagal nerve stimulation in dogs increases glucagon secretion via a nonmuscarinic mechanism and insulin secretion via a muscarinic mechanism, both of which are dependent on nicotinic transmission.
Åhrén et al. (1986) studied this question.
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