Key result
Electrical stimulation of the dorsal vagus nerve significantly increased plasma glucagon and insulin concentrations in anesthetized dogs, an effect abolished by atropinization.
Why the study?
Does electrical stimulation of the vagus nerve affect glucagon and insulin secretion in anesthetized dogs?
Population
Anesthetized dogs
Comparison
Electrical stimulation of the distal cut end of… vs Baseline/unstimulated state and atropinization
Design
Preclinical
Authors
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Vagal effects in anesthetized dogs warrant no clinical translation; leaves open autonomic islet regulation in humans.
Does electrical stimulation of the vagus nerve affect glucagon and insulin secretion in anesthetized dogs?
Physiological activation of the dorsal vagus nerve regulates both insulin and glucagon secretion from the pancreatic islets.
KANETO et al. (1974) studied this question. Electrical stimulation of the vagus nerves vs. Baseline / Atropinization was evaluated on Glucagon and insulin output from the pancreas. Electrical stimulation of the dorsal vagus nerve significantly increased plasma glucagon and insulin concentrations in anesthetized dogs, an effect abolished by atropinization.
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