Key result
Afferent vagal nerve stimulation caused a marked and sustained increase in blood glucose concentration (+108.9%) that was partly mediated by suppression of pancreatic insulin secretion.
Why the study?
Does selective efferent or afferent vagal nerve stimulation alter blood glucose, insulin, and glucagon concentrations in anesthetized rats?
Population
24 male normotensive Sprague Dawley rats (age 120 ± 4 days, 395 ± 9 g body weight)
Comparison
120 minutes of cervical vagal nerve stimulation… vs Baseline conditions before VNS
Design
Preclinical
Follow-up
120 minutes
Authors
Loading...
Afferent vagal stimulation may raise glucose in rats; hypothesis-generating for vagal therapies in diabetes, human data needed.
Does selective efferent or afferent vagal nerve stimulation alter blood glucose, insulin, and glucagon concentrations in anesthetized rats?
p-value: p=<0.05
Selective efferent vagal nerve stimulation increases insulin secretion and may be a potential therapeutic target for type II diabetes, whereas afferent stimulation causes sustained hyperglycemia.
Meyers et al. (2016) studied Healthy (normotensive rats) (n=24). Cervical vagal nerve stimulation vs. Baseline was evaluated on Blood glucose concentration (p=<0.05). Afferent vagal nerve stimulation caused a marked and sustained increase in blood glucose concentration (+108.9%) that was partly mediated by suppression of pancreatic insulin secretion.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: