Key result
The ACE gene D allele was associated with higher circulating ACE activity but not with increased left ventricular mass in healthy normotensive adults.
Why the study?
Is the ACE gene I/D polymorphism associated with plasma ACE activity and left ventricular mass in a healthy normotensive population?
Population
117 healthy normotensive subjects from a population-based study in Chile
Design
Cross-sectional
Authors
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ACE D allele raises plasma activity without LV mass effect in normotensives; leaves open genetic role in hypertrophy and requires prospective confirmation.
Cross-Sectional (n=117)
Is the ACE gene I/D polymorphism associated with plasma ACE activity and left ventricular mass in a healthy normotensive population?
In a healthy normotensive Chilean population, the ACE gene D allele is associated with higher plasma ACE activity but not with increased left ventricular mass.
Jorge Jalil (1999) conducted a cross-sectional in Healthy normotensive (n=117). ACE gene insertion/deletion (I/D) polymorphism vs. II genotype was evaluated on Plasma ACE activity and left ventricular (LV) mass. The ACE gene D allele was associated with higher circulating ACE activity but not with increased left ventricular mass in healthy normotensive adults.
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