Key result
Hereditary deficiencies of antithrombin, protein C, or protein S increased the annual incidence of venous thromboembolism compared to non-deficient relatives (1.76% vs 0.19%; RR 11.9, 95% CI 3.9-36.2).
Why the study?
Does hereditary deficiency of antithrombin, protein C, or protein S increase the risk of venous thromboembolism during pregnancy and puerperium?
Population
222 female relatives from families with hereditary antithrombin, protein C or protein S deficiencies
Comparison
Hereditary deficiencies of antithrombin, protein… vs Non-deficient female relatives
Design
Cohort
Authors
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Supports individualized prophylaxis decisions in deficient pregnancies; extends family cohort data but leaves optimal strategies unresolved.
Cohort (n=222)
Does hereditary deficiency of antithrombin, protein C, or protein S increase the risk of venous thromboembolism during pregnancy and puerperium?
Relative Risk: 11.9 (95% CI 3.9–36.2)
Absolute Event Rate: 1.76% vs 0.19%
Women with hereditary deficiencies of antithrombin, protein C, or protein S have a significantly increased risk of pregnancy-related venous thromboembolism, which is further elevated by multiple thrombophilic defects.
Folkeringa et al. (2007) conducted a cohort in Venous thromboembolism (n=222). Hereditary antithrombin, protein C or protein S deficiency vs. Non-deficient female relatives was evaluated on Annual incidence of venous thromboembolism (RR 11.9, 95% CI 3.9-36.2). Hereditary deficiencies of antithrombin, protein C, or protein S increased the annual incidence of venous thromboembolism compared to non-deficient relatives (1.76% vs 0.19%; RR 11.9, 95% CI 3.9-36.2).
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