Key result
Hereditary thrombophilias increase the risk of gestational venous thromboembolism independent of a positive family history of VTE.
Why the study?
Do hereditary thrombophilias increase the risk of gestational VTE independent of family history?
Observational
Do hereditary thrombophilias increase the risk of gestational VTE independent of family history?
Women with high-risk thrombophilia have an increased risk of gestational VTE independent of family history and should be considered for antenatal thromboprophylaxis.
Supports considering thrombophilia screening in pregnant women without family VTE history; leaves open prospective validation before practice change.
and prothrombin G20210A; 9.0% (6.1%) for antithrombin deficiency; 1.1% (0.7%) for protein C deficiency; and 1.0% (0.7%) for protein S deficiency. These results were independent of a positive family history of VTE. We provide evidence that unselected women with these thrombophilias have an increased risk of gestational VTE independent of a positive family history of VTE. In contrast to current guidelines, these data suggest that women with high-risk thrombophilia should be considered for antenatal thromboprophylaxis regardless of family history of VTE.
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Gerhardt et al. (2016) conducted an observational in Venous thromboembolism during pregnancy and the puerperium. Hereditary thrombophilias (e.g., antithrombin, protein C, or protein S deficiency) was evaluated on Gestational venous thromboembolism (VTE). Hereditary thrombophilias increase the risk of gestational venous thromboembolism independent of a positive family history of VTE.
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