Hereditary thrombophilias increase the risk of gestational venous thromboembolism independent of a positive family history of VTE.
Observational
and prothrombin G20210A; 9.0% (6.1%) for antithrombin deficiency; 1.1% (0.7%) for protein C deficiency; and 1.0% (0.7%) for protein S deficiency. These results were independent of a positive family history of VTE. We provide evidence that unselected women with these thrombophilias have an increased risk of gestational VTE independent of a positive family history of VTE. In contrast to current guidelines, these data suggest that women with high-risk thrombophilia should be considered for antenatal thromboprophylaxis regardless of family history of VTE.
Gerhardt et al. (Sat,) conducted a observational in Venous thromboembolism during pregnancy and the puerperium. Hereditary thrombophilias (e.g., antithrombin, protein C, or protein S deficiency) was evaluated on Gestational venous thromboembolism (VTE). Hereditary thrombophilias increase the risk of gestational venous thromboembolism independent of a positive family history of VTE.