Key result
Doxorubicin increases cardiac enzymes and causes myocardial necrosis, edema, and thrombosis in rats.
Why the study?
Does doxorubicin cause histopathological and biochemical changes in the heart of white rats?
Does doxorubicin cause histopathological and biochemical changes in the heart of white rats?
p-value: p=<0.05
Doxorubicin induces significant biochemical and histopathological cardiac damage in a rat model, highlighting its cardiotoxic effects.
The aim of this study is to know the effect of doxorubicin on the function of heart. The drug was administrated for three and six weeks. The animals were sacrified after 48 hr. of the last inject. This study revealed a significant increases in the activity of lactate dehydrogenase and Creatine Kinase enzyme in the rats' serum when administrated the animal doxorubicin intraperit oneally, for 3 weeks and not significantly increase when administrated for six weeks. Histopathological changes in cardiac tissues revealed a congestion in the blood vessels thrombus and thickness of the wall blood vessels, a dilation of the blood vessels, a prevascular infilteration of the inflammatory cells, infilteration of the inflammatory cells in cardiac muscle, focal lymphocyte infiltration, oedema, hyalinization and loss of striation.
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Ali et al. (2017) studied Cardiotoxicity (n=50). Doxorubicin vs. Normal saline was evaluated on Serum Lactate Dehydrogenase (LDH) and Creatine Kinase (CK) enzyme activity (p=<0.05). Doxorubicin administered intraperitoneally for 3 weeks significantly increased serum LDH and CK activity and caused histopathological cardiac damage including necrosis, oedema, and thrombosis in rats.
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