Key result
Elevated biomarkers (BNP, NT-pro-BNP, and cTnT) were significantly related to cardiac dysfunction in 6 of 14 studies, suggesting utility in early detection of anthracycline-induced cardiotoxicity.
Why the study?
Do biomarkers (BNP, NT-pro-BNP, cTnT, cTnI) help in the early detection of anthracycline-induced cardiotoxicity in children?
Do biomarkers (BNP, NT-pro-BNP, cTnT, cTnI) help in the early detection of anthracycline-induced cardiotoxicity in children?
Biomarkers such as BNP, NT-pro-BNP, and cTnT may be useful for the early detection of anthracycline-induced cardiotoxicity in pediatric cancer survivors.
Answers are grounded in this paper and cite their sources.
May support biomarker monitoring in children receiving anthracyclines; leaves open the need for prospective validation before clinical adoption.
Anthracycline-induced cardiotoxicity can cause serious health problems for an increasing number of children surviving childhood malignancies. Early detection of cardiac failure is critically important for the prevention and management of anthracycline-induced cardiotoxicity. The aim of this research was to determine the role of biomarkers in the early detection of anthracycline-induced cardiotoxicity in children. A literature review is presented of studies regarding the use of the biomarkers B-type natriuretic peptide (BNP), N-terminal pro-BNP (NT-pro-BNP), cardiac troponin T (cTnT), and cardiac troponin I (cTnI) in relation with anthracycline-induced cardiotoxicity in children. Six of 14 studies in children showed a significant relation between elevated biomarkers BNP, NT-pro-BNP, and cTnT and cardiac dysfunction. Six studies, although small, suggest that BNP, NT-pro-BNP, and cTnT might be useful markers in the early detection of anthracycline-induced cardiotoxicity.
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Mavinkurve‐Groothuis et al. (2008) conducted a review in Anthracycline-induced cardiotoxicity. Biomarkers (BNP, NT-pro-BNP, cTnT, cTnI) was evaluated on Relation between elevated biomarkers and cardiac dysfunction. Elevated biomarkers (BNP, NT-pro-BNP, and cTnT) were significantly related to cardiac dysfunction in 6 of 14 studies, suggesting utility in early detection of anthracycline-induced cardiotoxicity.
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