Why the study?
Do cardiac troponins and natriuretic peptides improve the early detection and prediction of anthracycline cardiotoxicity in childhood cancer survivors compared to standard imaging?
Do cardiac troponins and natriuretic peptides improve the early detection and prediction of anthracycline cardiotoxicity in childhood cancer survivors compared to standard imaging?
Cardiac troponins and natriuretic peptides may offer an advantageous approach for the early detection and prediction of anthracycline-induced cardiotoxicity compared to traditional imaging.
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May support biomarker surveillance in anthracycline-exposed children; leaves open prospective validation versus imaging before practice change.
Anthracycline-related cardiotoxicity has a substantial negative impact on long-term survivors of childhood cancer. The detection of cardiotoxicity is currently based on echocardiography or radionuclide angiography. However, as they depict only the final outcome of myocardial injury in terms of reduced heart contractility, heart specific biomarkers of myocardial destruction or dysfunction could be advantageous by allowing for an earlier detection of cardiotoxicity. In the present study, the usefulness of cardiac troponins and natriuretic peptides, the most commonly used biomarkers of myocardial destruction and ventricular dysfunction respectively, to detect and to predict the development of anthracycline cardiotoxicity has been reviewed.
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Germanakis et al. (2008) studied this question.
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