Key result
Concurrent administration of intravenous magnesium with ibutilide increased the odds of successful chemical conversion of atrial fibrillation or flutter (AOR 1.78; 95% CI 1.02-3.09).
Why the study?
Does intravenous magnesium sulfate improve successful chemical conversion in patients receiving intravenous ibutilide for atrial fibrillation or flutter?
Population
229 consecutive patients with atrial fibrillation or flutter receiving intravenous ibutilide
Comparison
Intravenous magnesium sulfate concurrent with… vs Intravenous ibutilide without adjunctive magnesium
Design
Cohort
Authors
Loading...
Magnesium co-administration was associated with higher ibutilide conversion rates; hypothesis-generating and requires randomized confirmation before practice change.
Cohort (n=229)
Does intravenous magnesium sulfate improve successful chemical conversion in patients receiving intravenous ibutilide for atrial fibrillation or flutter?
Odds Ratio: 1.78 (95% CI 1.02–3.09)
Adjunctive intravenous magnesium sulfate, particularly at a 4-gram dose, significantly increases the efficacy of intravenous ibutilide for the chemical conversion of atrial fibrillation or flutter.
Tercius et al. (2007) conducted a cohort in Atrial Fibrillation or Flutter (n=229). Intravenous magnesium sulfate vs. No adjunctive magnesium was evaluated on Successful chemical conversion (AOR 1.78, 95% CI 1.02-3.09). Concurrent administration of intravenous magnesium with ibutilide increased the odds of successful chemical conversion of atrial fibrillation or flutter (AOR 1.78; 95% CI 1.02-3.09).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: