Key result
Prophylactic IV magnesium is linked to ~19% higher ibutilide cardioversion success vs. no magnesium.
Why the study?
The impact of prophylactic intravenous magnesium on the efficacy of ibutilide for conversion of atrial fibrillation or flutter was not well established.
Does prophylactic intravenous magnesium improve successful chemical cardioversion in patients receiving ibutilide for atrial fibrillation or flutter?
Population
321 patients receiving ibutilide for acute chemical conversion of atrial fibrillation or flutter at three tertiary care centers
Comparison
Prophylactic intravenous magnesium vs no magnesium before or during ibutilide therapy
Design
Multicenter cohort study
Authors
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Magnesium coadministration was associated with higher ibutilide success rates; leaves open need for prospective confirmation before practice change.
Cohort (n=321)
Yes
Does prophylactic intravenous magnesium improve successful chemical cardioversion in patients receiving ibutilide for atrial fibrillation or flutter?
p-value: p=0.040
Prophylactic intravenous magnesium enhances the efficacy of ibutilide for chemical cardioversion of atrial fibrillation or flutter and reduces the need for direct-current cardioversion.
Kalus et al. (2003) conducted a cohort in atrial fibrillation or flutter (n=321). prophylactic i.v. magnesium vs. no magnesium was evaluated on successful chemical cardioversion (p=0.040). Prophylactic i.v. magnesium administration was associated with an approximately 19% higher rate of successful chemical cardioversion with ibutilide compared to no magnesium (p=0.040).
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