Key result
The percutaneous circulatory support device significantly unloaded the left ventricle, decreasing left atrial pressure from 25 to 20 mm Hg (p=0.008) in calves with induced heart failure.
Why the study?
Does a new percutaneous circulatory support device improve hemodynamics in a calf model of induced left ventricular failure?
Does a new percutaneous circulatory support device improve hemodynamics in a calf model of induced left ventricular failure?
Absolute Event Rate: 20% vs 25%
p-value: p=0.008
The new percutaneous circulatory support device successfully unloaded the left ventricle and increased lower body perfusion pressure in a calf model of heart failure.
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Supports preclinical LV unloading data; leaves open human safety and efficacy pending trials.
Reitan et al. (2003) studied Induced left ventricular failure (n=7). Percutaneous circulatory support device vs. Baseline was evaluated on Left atrial pressure (mm Hg) (p=0.008). The percutaneous circulatory support device significantly unloaded the left ventricle, decreasing left atrial pressure from 25 to 20 mm Hg (p=0.008) in calves with induced heart failure.