This preclinical study determined the loop gain and time response of the renin-angiotensin system in a canine model without central nervous system cardiovascular control.
Neural inputs modulate RAS dynamics in canines; leaves open translation to human cardiovascular regulation.
The loop gain and time response of the renin-angiotensin system was determined in dogs in which the cardiovascular control loops of the central nervous system were eliminated by spinal cord destruction and decapitation.
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Cowley et al. (1971) studied this question.
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